Abstract
Animals must continually evaluate stimuli in their environment to decide which opportunities to pursue, and in many cases these decisions can be understood in fundamentally economic terms. Although several brain regions have been individually implicated in these processes, the brain-wide mechanisms relating these regions in decision-making are unclear. Using an economic decision-making task adapted for rats, we find that neural activity in both of two connected brain regions, the ventrolateral orbitofrontal cortex (OFC) and the dorsomedial striatum (DMS), was required for economic decision-making. Relevant neural activity in both brain regions was strikingly similar, dominated by the spatial features of the decision-making process. However, the neural encoding of choice direction in OFC preceded that of DMS, and this temporal relationship was strongly correlated with choice accuracy. Furthermore, activity specifically in the OFC projection to the DMS was required for appropriate economic decision-making. These results demonstrate that choice information in the OFC is relayed to the DMS to lead accurate economic decision-making.
Felicity Gore, Melissa Hernandez, Charu Ramakrishnan, Ailey K. Crow, Robert C. Malenka & Karl Deisseroth. Orbitofrontal cortex control of striatum leads economic decision-making. Nature Neuroscience, 2023-8. [LINK]
Speaker: Qianru Zhang
Time: 9:00 am, 2023/9/25
Location: CIBR A622
