Abstract
Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. Activity-dependent plasticity of synaptic input is a major underlying cellular process. Although we have a detailed understanding of synaptic and dendritic plasticity in vitro, little is known about the functional and plastic properties of active dendrites in behaving animals. Using deep brain two-photon Ca2+ imaging, we investigated how sensory responses in amygdala principal neurons develop upon classical fear conditioning, a form of associative learning. Fear conditioning induced differential plasticity in dendrites and somas regulated by compartment-specific inhibition. Our results indicate that learning-induced plasticity can be uncoupled between soma and dendrites, reflecting distinct synaptic and microcircuit-level mechanisms that increase the computational capacity of amygdala circuits.
d’Aquin, S., Szonyi, A., Mahn, M., Krabbe, S., Gründemann, J., & Lüthi, A. (2022). Compartmentalized dendritic plasticity during associative learning. Science, 376(6590), eabf7052.[LINK]
Speaker: Zhaoyang Yin
Time: 9:30 am, 2022/10/8
Location: CIBR A6 Meeting Room
