• Home
  • People
    Current Members
    Lab Alumni
  • Research
    Overview
    Highlights
    Methods & Tools
  • Publications
  • News
  • Resources
  • Join Us
  • Home
  • People
    Current Members
    Lab Alumni
  • Research
    Overview
    Highlights
    Methods & Tools
  • Publications
  • News
  • Resources
  • Join Us
Home > Journal Club & Teaching

Journal Club & Teaching

Secondary auditory cortex mediates a sensorimotor mechanism for action timing

Abstract

The ability to accurately determine when to perform an action is a fundamental brain function and vital to adaptive behavior. The behavioral mechanism and neural circuit for action timing, however, remain largely unknown. Using a new, self-paced action timing task in mice, we found that deprivation of auditory, but not somatosensory or visual input, disrupts learned action timing. The hearing effect was dependent on the auditory feedback derived from the animal's own actions, rather than passive environmental cues. Neuronal activity in the secondary auditory cortex was found to be both correlated with and necessary for the proper execution of learned action timing. Closed-loop, action-dependent optogenetic stimulation of the specific task-related neuronal population within the secondary auditory cortex rescued the key features of learned action timing under auditory deprivation. These results unveil a previously underappreciated sensorimotor mechanism in which the secondary auditory cortex transduces self-generated audiomotor feedback to control action timing.


Cook, J. R., Li, H., Nguyen, B., Huang, H. H., Mahdavian, P., Kirchgessner, M. A., ... & Jin, X. (2022). Secondary auditory cortex mediates a sensorimotor mechanism for action timing. Nat Neurosci, 25(3), 330-344.[LINK]


Speaker: Qianru Zhang

Time:9:30 am, 2022/07/01

Location: CIBR Phase I South, Floor 2

  • People
  • Research
  • Publications
  • News
  • Resources
  • Join Us
  • 北京脑科学与类脑研究所 - 周景峰实验室
  • Chinese Institute for Brain Research, Beijing
  • Bldg 3, 9 Yike Rd, ZGC Life Sci Park, Changping, Beijing 102206

2024 © Zhou Lab - Chinese Institute for Brain Research, Beijing - 京ICP备18029179号 ❀